Identification of a four-miRNA signature predicts the prognosis of papillary thyroid cancer

Figure 1 Volcano plot of 2202 miRNAs in papillary thyroid cancer patients. The red color indicates up-regulated expression, and the green color represents down-regulated expression. FDR: False discovery rate; FC: Fold change.

Figure 2 The distribution of the risk score, overall survival, and overall survival status and the heat map of the prognostic four-miRNA signature. A: The training cohort; B: Test cohort. The dotted line indicates the cutoff point of the median risk score, which is used to stratify patients into the low-risk and high-risk groups.

Figure 3 Kaplan-Meier curves of overall survival and time-dependent receiver operating characteristic curves of the 5-year survival rate for papillary thyroid cancer patients based on the four-miRNA signature. A and C: Training cohort; B and D: Test cohort. AUC: Area under the curve; ROC: Receiver operating characteristic.

Figure 4 Prognostic nomogram and calibration plots of the four-miRNA signature. A: The prognostic nomogram based on the four-miRNA signature; B and C: Calibration plots of the four-miRNA-based prognostic model in the training and test cohorts of the 3-year survival rate; D and E: Calibration plots of the four-miRNA-based prognostic model in the training and test cohorts of the 5-year survival rate.

Figure 5 Validation the four-miRNA signature in transcriptome sequencing cohort. A: Overall survival curves; B: Recurrence-free survival curves in the whole-transcriptome sequencing cohort.