Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules

Table 3 Allergen molecules of domestic insect pest origin¹ used in singleplex and multiplex immunoassays[9,74,104]

Allergen molecule	Biological function, comments, CR
Cockroaches (Blattella germanica, Periplaneta americana)
rBla g 1	Midgut microvilli protein-homolog CR Per a 1 (group 1),
	secreted in the digestive system and excreted in fecal particles,
	concentration in feces of adult females higher vs adult males and nymphs
rBla g 2	Unusual inactive aspartic protease with strong allergenic properties
	Digestive organs (esophagus, gut and proventriculus) and fecal particles
rBla g 4	Insect calycin lipocalin, calcium binding protein,
	binds tyramine/octopamine with role in reproduction of insects
rBla g 5	GST
	Involved in detoxification of toxic compounds role in insecticide resistance
rPer a 7	Invertebrate tropomyosin, muscle contraction protein,
	invertebrate panallergen CR Bla g 7, locomotor insect body parts

¹n: Native purified;

r: Recombinant; Cockroaches Blattella germanica (Bla g) and Periplaneta americana (Per a) allergen molecules; CR: Cross-reactivity; GST: Glutathione S-transferase.