Is forced oscillation technique the next respiratory function test of choice in childhood asthma

Table 3 Reported bronchodilator responsiveness in young healthy and wheezy children using forced oscillation technique since 2005

Ref.	Ethnic group age, yr	n	Variable	Dose	Waiting time (n)	Absolute BDR	Relative BDR, (%)
Thamrin et al[53], 2007	Healthy Caucasian (3-7)	78	Rrs 6,8,10 Xrs 6,8,10	Salbutamol 600 mg	15	Rrs 6 -35.0, -3.1 Rrs 8 -35.0, -4.4 Rrs 10 -32.3, -3.7 Xrs 6 -0.27, 1.66 Xrs 8 - 0.04, 1.82 Xrs 10 -0.00, 2.03	Rrs 6: 42% Rrs 8: 37% Rrs 10: 39% Xrs 6: 61% Xrs 8: 67% Xrs 10: 63%
Thamrin et al[53], 2007	Asthmatics Caucasian (3-7)	57	Rrs 6, 8, 10 Xrs 6, 8, 10	Salbutamol 600 µg	15	Rrs 6 -37.0, 8.8 Rrs8 -33.1, 9.7 Rrs 10 -33.4, 4.5 Xrs 6 -0.21, 2.30 Xrs 8 -0.13, 2.47 Xrs 10 -0.12, 2.22	Rrs 6: 42% Rrs 8: 37% Rrs 10: 39% Xrs 6: 61% Xrs 8: 67% Xrs 10: 63%
Lan Vu et al[39], 2008	Healthy Vietnamese (6–11)	175	Rrs 8 Hz Xrs 8 Hz	Salbutamol 200 µg	5	Rrs 8 -11.8,13.4 Xrs 8 4.09, - 5.78	Rrs 8: 38% Xrs 8: 16%
Lan Vu et al[40], 2010	Asthmatic Vietnamese (6-10)	103	Rrs 8 Hz Xrs 8 Hz	Salbutamol 200 µg	5	--	Rrs 8: 13% Xrs: 32%
Oostveen et al[55], 2010	Asthmatic Belgian -4	313	Rrs 4	Salbutamol 200 µg	15	--	Rrs 4: 22% AX: 15.77%
Calogero et al[41], 2010	Healthy Italian (3-6)	163	Rrs 8 Xrs8	Salbutamol 200 µg	15	--	Rrs 8: 35% Xrs 8: 34%-61%
LEE et al[57], 2012	Healthy Korean	161	Rrs 5, 10, 15, 20, 25, 35 Xrs 5, 10, 15, 20, 25, 35	Salbutamol 200 µg	15	Rrs 5 -0.127 Rrs 10 -0.098 Rrs 15 -0.073 Rrs 20 -0.056 Rrs 25 -0.056 Rrs 35 -0.057 Xrs 5 0.062 Xrs 10 0.057 Xrs 15 0.059 Xrs 20 0.044 Xrs 25 0.033 Xrs 35 0.054 Fres -2.167	Rrs 5: 11.8 Rrs 10: 10.8 Rrs 15: 8.7 Rrs 20: 6.972 Rrs 25: 7.029 Rrs 35: 6.095 Xrs 5: 13.474 Xrs 10: 25.946 Fres: 10.457
Calogero et al[43], 2013	Healthy Australian and Italian (2-16)	502	Rrs 6, 8, 10 Xrs 6, 8, 10 Fres, AX	Salbutamol 200 µg	15	Rrs 6 -2.9 Rrs 8 -2.74 Rrs 10 -2.39 Xrs 6 -1.80 Xrs 8 - 1.93 Xrs 10 -1.90 AX -33 Fres -12	Rrs 6: 34 Rrs 8: 32 Rrs 10: 31 Xrs 6: 50 Xrs 8: 65 Xrs 10: 74 AX: 81 Fres: 47

BDR: Bronchodilator responsiveness; Rrs: Respiratory system resistance; Xrs: Respiratory system reactance in hPa/s per L; Fres: Resonant frequency; AX: Area under the Xrs curve from 5 Hz to Fres; MF: Multi-frequency system; Fdep: Frequency dependence of Rrs between 4-24 Hz.