Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate

Figure 1 Modification of Diet in Renal Disease[22] and Chronic Kidney Disease Epidemiology Collaboration[23] formulae for estimating glomerular filtration rate fit to variations in serum creatinine (X axis) and age (Y axis) assuming males of Caucasian race. Note that the CKD-EPI formula yields slightly higher eGFR values with higher serum creatinine values and lower age whereas the MDRD formula leads to significantly higher eGFR values at very low serum creatinine values. MDRD: Modification of Diet in Renal Disease; CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration; eGFR: Estimating glomerular filtration rate.