Targeted temperature management in neurological intensive care unit

Table 2 Summary of the landmark randomized control trials for targeted temperature management in post-cardiac arrest syndrome

	Australian trial	European trial
Sample size	n = 77	n = 275
TTM vs untreated	43 TTM vs	137 TTM vs
	34 untreated	138 untreated
Initial rhythm	VT/VF	VT/VF
Method of TTM	Surface with ice packs	Surface with cooling blankets/pads and ice packs
Place of initiation	Emergency department	Prehospital setting
Target temperature	33 °C	32 °C-34 °C
Duration of TTM	12 h	24 h
Time of Follow up	30 d	6 mo
Outcomes	NNT of 7 to avoid death	NNT of 6 to improve neurological outcomes

TTM: Targeted temperature management; VF: Ventricular fibrillation; VT: Ventricular tachycardia; NNT: Number-needed-to-treat.