Methods, units and quality requirements for the analysis of haemoglobin A1c in diabetes mellitus

Table 2 The methods commonly used for analyzing hemoglobin A_1c according to the surveys conducted by Labquality Ltd. in 2015

Numerical summary from a diabetic EDTA-blood sample 5/2015
Analyte/method group	Mean	SD	CV%	Min	Max	Number
HbA1c, mmol/mol
Abbott Arhitect enzymatic	53.64	2.45	4.6	48.4	32.1	6
Axis-Shield Afinion	54.70	2.17	4.0	51.0	58.0	44
Beckman Coulter	55.2					1
Hemoque	51.4	3.98	7.7	46.0	55.0	5
HPLC Bio-Rad D-10	55.00					1
HPLC Bio-Rad Variant	56.00	3.21	5.7	54.0	58.0	2
HPLC Tosoh	56.42	1.23	2.2	35.6	59.8	33
Roche Cobas c Tina-Quant	54.76	2.56	4.7	33.0	57.0	13
Roche Cobas Integra	55.0					1
Rocgw Tina Quant	56.00					1
Siemens Advia Centaur	57.93					1
Siemens DCA 2000+ and Vant	55.05	1.96	3.6	51.0	58.0	33
Thermo Scientific Konelab	54.44	2.63	4.8	48.0	58.4	24
All	55.05	2.17	3.9	32.1	59.8	165
HbA1c
Abbott Arhitect enzymatic	7.20	0.00	0.0	7.2	7.2	3
Axis-Shield Afinion	7.17	0.21	2.9	6.9	7.5	44
Beckman Coulter	7.2					1
Hemoqe	6.88	0.25	3.7	6.6	7.2	6
HPLC Bio-Rad D-10	7.2					1
HPLC Bio-Rad Variant	7.5					1
HPLC Tosoh	7.34	0.13	1.8	7.0	8.8	23
Roche Cobas c Tina-Quant	7.29	0.12	1.6	6.7	7.4	7
Siemens Advia Centaur	7.45			5.8	7.0	1
Siemens DCA 2000+ and Vant	7.19	0.18	2.6	6.8	7.5	31
Thermo Scientific Konelab	7.13	0.25	3.5	6.6	7.5	26
All	7.20	0.21	2.9	6.6	8.8	143

HbA_1c: Hemoglobin A_1c.