Copyright
©The Author(s) 2016.
World J Methodol. Mar 26, 2016; 6(1): 112-117
Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.112
Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.112
Figure 2 Liver fibrosis creation followed down-regulating of peroxisome proliferator-activated receptor-γ after liver injury.
As shown, decrease in PPAR-γ expression after liver injury causes an increase in HSC DNA expression and HSC activation. This regulation also results in increased expression of α-SMA, collagen, ECM and TGF-β and induces liver fibrosis. PPAR-γ: Peroxisome proliferator-activated receptor-γ; HSC: Hepatic stellate cell; TGF: Transforming growth factor; ECM: Extracellular matrix; α-SMA: α-smooth muscle actin.
- Citation: Mazidi M, Karimi E, Meydani M, Ghayour-Mobarhan M, Ferns GA. Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo. World J Methodol 2016; 6(1): 112-117
- URL: https://www.wjgnet.com/2222-0682/full/v6/i1/112.htm
- DOI: https://dx.doi.org/10.5662/wjm.v6.i1.112