Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer

doi:10.5662/wjm.v6.i1.43

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Mar 26, 2016; 6(1): 43-55
Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.43

Table 2 Leptin signaling impacts on pancreatic cancer progression

Treatments	Human pancreatic cancer cell lines
	BxPC-3 less aggressive				MiaPaCa-2 more aggressive		Panc-1 more aggressive
	Control	Leptin	Leptin + CT	Leptin+ CT + LI	Control	Leptin	Control	Leptin	CT	Leptin + CT	Leptin + CT + LI
Proliferation (%)	100	212²			100	120²	100	130²
Survival¹ (%)	100	100	63²	55²			100	100	35²	41²	36²
PCSC (%)	100	130-140			100	120-130
Notch1	100	170²			100	NC
Notch2	100	147²			100	75
Notch3 (%)	100	NC			100	NC
Notch4	100	71			100	146²
Tumorsphere formation (%)	100	197²			100	184²	100	221²

¹Cell survival was determined by flow cytometry and MTT assays in media containing 10% fetal bovine serum (BxPC-3) or serum free medium containing leptin (Panc-1);

²Statistically significant (P < 0.05) vs control. CT: Chemotherapy, LI: Leptin inhibitor 90; PCSC: Pancreatic cancer stem cell markers; NC: No change.

Citation: Lipsey CC, Harbuzariu A, Daley-Brown D, Gonzalez-Perez RR. Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer. World J Methodol 2016; 6(1): 43-55
URL: https://www.wjgnet.com/2222-0682/full/v6/i1/43.htm
DOI: https://dx.doi.org/10.5662/wjm.v6.i1.43