Helicobacter pylori and allergy: Update of research

Table 1 Association between Helicobacter pylori and allergy in cross-sectional studies

Ref.	Country	Studied population	n	Age (yr)	H. pylori detection	Allergy diagnosis	Main finding: OR (95%CI) in relation to H. pylori
Lee et al[35]	South Korea	Routine check-up	3376	Adults	IgG	Physician diagnosed allergy; use of anti-allergic medication; IgE	No association with allergic disease: 1.05 (0.86-1.28);
							Inverse association with IgE hypersensitivity: 1.32 (0.98-1.31)
Zevit et al[46]	Israel	National referral laboratory	6959	5-18	UBT	Physician diagnosed asthma; use of anti-allergic medication	Inverse association with asthma: 0.82 (0.69-0.08)
Imamura et al[47]	Japan	Healthy volunteers	211	Adults	IgG	Specific IgE, polinosis symptoms	Inverse association with polinosis: 0.15 (0.05-0.48)
Fullerton et al[21]	United Kingdom	General population	2437	Adults	IgG	Symptoms of wheeze, hay fever; lung function tests; bronchial reactivity; SPT; IgE	No association with asthma: 1.09 (0.77-1.54), atopy: 0.92 (0.74-1.15); hay fever: 1.00 (0.79-1.26), wheeze: 0.94 (0.74-1.19)
Pfefferle et al[48]	Germany	Employees of two companies	500	Adults	SAT	Self-reported physician diagnosed allergy, use of anti-allergic medication specific skin sensitization	Inverse association with allergy diagnosis: 0.26 (0.08-0.84)
							Chen et al[13]	United States	Data from health and nutrition examination survey	7412	3-19	IgG; CagA	Self-reported asthma	Inverse association with asthma: 0.69 (0.45-1.06) Subgroup < 5 yr: 0.58 (0.38-0.88); 3-13 yr: 0.14 (0.24-0.69)
Shiotani et al[49]	Japan	University students	1953	Adults	IgG	Self-reported atopic dermatitis, asthma, allergic rhinitis, urticaria	Inverse association with allergic diseases: 0.49 (0.27-0.89)
Baccioglu et al[50]	Turkey	Patients with upper gastrointestinal endoscopy	90	Adults	Gastric tissue microscopy	SPT, total IgE, questionnaire	No association with allergic disease: 1.0 (0.1-18.9)
							Inverse association with asthma/CagA+ cases: 0.79 (0.63-0.99);
Chen et al[12]	United States	Data from health and nutrition examination survey	7663	Adults	CagA	Self-reported asthma, allergen-specific skin sensitization	Inverse association with allergic rhinitis/CagA+: 0.77 (0.62-0.96)
Herbarth et al[51]	Germany	School starters	3347	5-7	UBT	Eczema	Inverse association with eczema: OR 0.31
Kolho et al[52]	Finland	Patients with upper gastrointestinal endoscopy	97	5-15	Histology data	Specific IgE	No association with IgE, asthma, hay fever;
Jarvis et al[20]	United Kingdom	Health service registry	1121	Adults	IgG	Specific IgE, symptoms	Inverse association with sensitization to grass: 0.65 (0.43-0.99)
Uter et al[53]	Germany	University students	1368	18-20	IgG	Physician diagnosed asthma	No association with asthma: 0.99 (0.57-1.64)
McCune et al[54]	United Kingdom	Community-based population	3244	Adults	UBT	Use of asthma medication	Inverse association with asthma: 0.78 (0.59-1.05)

H. pylori: Helicobacter pylori; UBT: 13C-urea breath test; SAT: Stool antigen test; SPT: Skin prick test.