Immunodiagnosis of human hydatid disease: Where do we stand?

Table 3 Performances of antigen B in diagnosis of cystic echinococcosis

Antigen	No. of subjects			Test	Sensitivity (%)	Specificity (%)	Cross reactions	Year	Ref.
	CEpatients	Other disease	Healthy control
nAg B	204	21	90	IB	66	100	None	2000	[75]
nAg B	59	55	15	IgG ELISA	80	77	AE, NCC	2005	[77]
nAg B	90	86	27	IgG ELISA	77	85	AE, RA	2000	[9]
nAg B	204	21	90	IgG ELISA	74	100	None	2000	[75]
nAg B	31	87	29	IgG ELISA	77.41	81.9	AE, Ev, Schist, Toxoc	2000	[78]
nAg B	78	24	15	IgG ELISA	93.5	89.7	Distomatosis, Schist	2001	[71]
nAg B	129	65	203	IgG ELISA	60.3	92.6	Cysts,Toxoc	2003	[44]
nAg B	22	12	4	WB	77	100	Toxoc, Other cestodes	2010	[30]
nAg B	40	40	70	IgG ELISA	92.5	97.3	Fascio	2007	[10]
nAg B	40	40	70	CCIEP	97.5	58.2	Fascio, Toxoc, Taenia, Malignancy	2007	[10]
nAg B	204	53	90	IB	66	100	None	2000	[75]
nAg B	204	53	90	IgG ELISA	74	100	None	2000	[75]
nAg B	35	29	25	IgG ELISA	94.2	81.6	NR	2009	[16]
nAg B	55	72	50	IgG ELISA	96.4	97.2	None	2014	[68]
nAg B	113	112	121	DIGFA	92.9	81	HD, Cysts, HCC, HH	2015	[48]
Goat liver Ag B	47	30	40	IgG ELISA	91.4	92.8	NR	2011	[49]
Human liver Ag B	47	30	40	IgG ELISA	97.8	97.1	NR	2011	[49]
Bovine lung Ag B	47	30	40	IgG ELISA	78.7	85.7	NR	2011	[49]
Sheep lung Ag B	47	30	40	IgG ELISA	93.6	88.5	NR	2011	[49]
Camel lung Ag B	47	30	40	IgG ELISA	93.6	90	NR	2011	[49]
Sheep liver Ag B	47	30	40	IgG ELISA	95.7	92.8	NR	201	[49]
rAgB	204	21	90	IB	72	100	None	2000	[75]
rAgB	113	112	121	DIGFA	77.9	98.3	None	2015	[48]
rAgB8/1	31	87	29	IgG ELISA	54.84	80.17	AE, Schist, Toxoc	2000	[78]
rAgB8/1	129	65	203	IgG4 ELISA	91.4	91.7	Cysts	2003	[44]
rAgB8/1	59	55	15	IgG ELISA	68	88	AE, NCC	2005	[80]
rAgB8/2	31	87	29	IgG ELISA	83.87	98.28	Schist, Toxoc	2000	[78]
rAgB8/2	129	65	203	IgG ELISA	93.1	99.5	Cysts, Toxoc	2003	[45]
rAgB8/2	129	65	203	IgG4 ELISA	69	87.5	Cysts	2003	[45]
rAgB8/2	59	55	15	IgG ELISA	45	86	AE, NCC	2005	[77]
rAgB8/1	129	65	203	IgG4 ELISA	91.4	91.7	Cysts	2003	[44]
rAgB8/1	59	55	15	IgG ELISA	68	88	AE, NCC	2005	[77]
rAgB8/2	31	87	29	IgG ELISA	83.87	98.28	Schist, Toxoc	2000	[78]
rAgB8/2	129	65	203	IgG ELISA	93.1	99.5	Cysts, Toxoc	2003	[44]
rAgB8/2	129	65	203	IgG4 ELISA	69	87.5	Cysts	2003	[44]
rAgB8/2	59	55	15	IgG ELISA	45	86	AE, NCC	2005	[77]
B1t	102	68	95	IgG ELISA	83.3	87.5	AE, Schist, Cysts, Fascio,	2008	[9]
B2t	102	68	95	IgG ELISA	91.2	93	Cysts, Schist, Fascio	2008	[9]
2B2t	186	174	110	IgG ELISA	87.6	99.1	AE, NCC, Hepatitis	2012	[9]
rEgAFFPt	129	65	203	IgG ELISA	58.6	95.6	Cysts, Toxoc	2003	[44]
rEgCaBP2	129	65	203	IgG ELISA	84.5	96.6	Cysts, Toxoc	2003	[44]
rEgcMDH	129	65	203	IgG ELISA	89.7	95.1	Cysts	2003	[44]
rEgAFFPf	129	65	203	IgG ELISA	69	89.7	Cysts, Toxoc	2003	[44]
rEpC1-GST	324	502	70	IgG IB	92.2	95.6	AE, NCC, Schist,	2003	[79]
							Liver cancer
rTPxEg	100	218	20	IgG IB	39	69.3	AE, NCC	2004	[78]
rEgG5	23	138	20	IgG IB	61	70	AE, Cysts	2004	[79]
E14t	102	68	95	IgG ELISA	35.3	91.7	Schist	2008	[9]
C317	102	68	95	IgG ELISA	58.8	80.9	AE, Cysts, Taeniasis, Schist,	2008	[9]
p65	90	86	27	IgG ELISA	44	96	AE, Schist, Toxoc	2000	[9]
p175	90	86	27	IgG ELISA	49	94	AE, Schist, Toxoc	2000	[9]
p176	90	86	27	IgG ELISA	80	93	AE, Schist, Toxoc,	2000	[9]
							Syph, Chagas
p177	90	86	27	IgG ELISA	38	92	AE, Toxoc, Syph,	2000	[9]
							Chagas
pGu4	90	86	27	IgG ELISA	18	98	AE	2000	[9]

Leish: Leishmaniasis; Toxop: Toxoplasmosis; Fascio: Fascioliasis; Cysts: Cysticercosis; Ascaris: Ascariasis; Syph: Syphilis; Ambs: Amebiasis; Toxoc: Toxocariasis; Schist: Schistosomiasis; NCC: Neurocysticercosis; AE: Alveolar echinococcosis; nAg B: Native antigen B; rAgB: Recombinant antigen B; Ev: Ev: Polycistic hydatid disease (E. vogeli); RA: Rheumatoid arthritis; HCC: Hepatocellular carcinoma; NR: Not reported; CE: Cystic echinococcosis; ELISA: Enzyme-linked immunosorbent assay.