Choosing inclusion criteria that minimize the time and cost of clinical trials

Figure 9 Cost estimates in a realistic test data set for targeted drug therapy of lung cancer, presented in Tables 2 and 3. Cost constants in thousands of dollars are as follows: screening cost per case c1 = 1, treatment cost c₂ = 10, opportunity cost c₃ = 100/year, case rate r = 50/year, follow up time t =1 year. Cost to the right of the dashed vertical asymptote are for a significant positive result (experimental treatment better than control). Costs to the left of the dashed vertical asymptote are for a significant negative result (experimental treatment worse than control).