Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Methodol. Jun 26, 2014; 4(2): 46-58
Published online Jun 26, 2014. doi: 10.5662/wjm.v4.i2.46
Table 2 Dynamic contrast-enhanced magnetic resonance imaging studies in breast cancer treatment assessment
Ref.Treatment methodDCE-MRI measurementMajor results
Dao et al[82] 1993Conserving radiation therapySignal intensityThe signal intensity over time in localized fibrosis showed a different pattern from the one in tumor recurrence; early increased signal intensity of the lesion within 3 min after CA administration were observed in recurrent tumors
Drew et al[83] 2001Neoadjuvant chemoradiotherapyDCE-MRI imageDCE-MRI detected the presence of residual disease with 100% accuracy
Hayes et al[16] 2002Neoadjuvant chemotherapyKtransThe absolute change in the Ktrans values correlated negatively with the pretreatment values. The trend is more obvious for responding patients
Martincich et al[38] 2004Primary chemotherapyECUECU reduction was associated with a MHR (OR = 2.50, 95%CI: 0.263-23.775); no statistical significance was observed (P = 0.42)
Overmoyer et al[84] 2004Antiangiogenic drugKepCorrelative studies suggested a reduction of tumor Kep and tumor MVD
Wedam et al[85] 2006Antiangiogenic drugKtrans and veKtrans decreased by 34.4% (P = 0.003), and ve was decreased by 14.3% (P = 0.002) after the treatment using bevacizumab
Yankeelov et al[52] 2007Neoadjuvant chemotherapyKtrans, ve, and τi (average intracellular water lifetime)Significant (P < 0.05) changes were seen in Ktrans and ve; Ktrans in voxels with values in 0.2-0.5 min-1 before treatment were found decreased (P < 0.035)
Chang et al[86] 2013SBRTiAUC5minThe mean iAUC5min in GTV increased from 1.93 ± 0.20 mmol-min to 2.31 ± 0.16 mmol-min, about 16% (P = 0.012) after treatment