An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications

Figure 7 Post-mortem study of necrotic and viable tissues in the liver and muscle from animal models either of reperfused partial liver infarction or ethanol-induced muscle necrosis pre-injected with iodine-123 labeled hypericin/hypericin followed by 1% Evans blue solution. A, B: Muscle; C, D: Liver. The hepatic infarction (A₁) and necrotic muscle (B₁) retain Evans blue as blue hyper intense areas, with viable liver (C₁) and normal muscle (D₁) without staining. Autoradiograms of 50-μm-thick sections show high tracer uptake in hepatic infarction (A₂) and muscle necrosis (B₂) but low accumulation either in viable liver (C₂) or muscle (D₂). The color code bar represents the code for the radioactivity concentration. By histology, the presence of hepatic infarction (A₃) and muscle necrosis (B₃) and the location of the viable liver (C₃) and muscle (D₃) tissues are verified.