An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications

Table 1 Evaluation of physical properties of different formulations of ¹²³Hyp/Hyp examined by macroscopic digital imaging under white light and ultraviolet light (254 nm) and by microscopy over a corresponding drop in bright field and fluorescence illumination mode

Formulation	Macroscopic digital imaging	Microscopy
DMSO/saline (20/80, v/v)	Cloudy brownish solution, no fluorescence	Massive formation of aggregates reduced fluorescent intensity
DMSO/water (25/75, v/v)	Cloudy brownish solution, no fluorescence	Massive formation of aggregate reduced fluorescent intensity
DMSO/D10W (25/75, v/v)	Cloudy brownish solution, no fluorescence	Massive formation of aggregates reduced fluorescent intensity
DMSO/D20W (25/75, v/v)	Cloudy brownish solution, no fluorescence	Massive formation of aggregates reduced fluorescent intensity
DMSO/serum (25/75, v/v)	Cloudy brownish solution, moderate fluorescence signal	Massive formation of aggregates moderate fluorescent intensity
DMSO/PEG 400/water (25/60/15, v/v/v)	Bright red solution, highly fluorescent	No aggregates formation; strong, homogeneous fluorescence
EtOH/PEG 400/water (10/50/40, v/v/v)	Dark red solution, moderate fluorescence	Aggregate formation; moderate, heterogeneous fluorescence,
EtOH/PEG 400/water (10/60/30, v/v/v)	Red solution, minimum aggregation, high fluorescence	Some aggregates; strong, homogeneous fluorescence
PEG 400/water (60/40, v/v)	Red solution, high fluorescence	Some aggregates; strong, homogeneous fluorescence
PEG 400/water (70/30, v/v)	Bright red solution, highly fluorescent	Some aggregates; strong, homogeneous fluorescence
PVP-10000	Dark red solution, moderate fluorescence	Aggregate formation; reduced fluorescence intensity
PVP-29000	Dark red solution, moderate fluorescence	Aggregate formation; reduced fluorescence intensity
β-Cyclodextrins	Cloudy brownish solution, no fluorescence	Massive formation of aggregates reduced fluorescent intensity

DMSO: Dimethyl sulfoxide; D10W: 10% dextrose; D20W: 20% dextrose; EtOH: Ethanol; PEG 400: Polyethylene glycol 400; PVP: Polyvinylpyrrolidone.