Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis

doi:10.5662/wjm.v15.i3.97415

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Sep 20, 2025 (publication date) through Mar 6, 2025

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Methodol. Sep 20, 2025; 15(3): 97415
Published online Sep 20, 2025. doi: 10.5662/wjm.v15.i3.97415

Table 4 Grade of evidence table¹

Outcomes	Anticipated absolute effects (95%CI)		Relative effect (95%CI)	No. of patients (studies)	Certainty assessment				Overall certainty of evidence
Outcomes	With standard EUS-FNA/B	With EUS-FNA/B and auxiliary techniques	Relative effect (95%CI)	No. of patients (studies)	Risk of bias	Inconsistency	Indirectness	Imprecision	Overall certainty of evidence
Sensitivity	0.82 (0.79-0.85)	0.86 (0.83-0.89)	RR: 1.04 (0.99-1.09)	1471 (9 studies)	+	+	-	-	Low
Specificity	1.00 (0.96-1.00)	1.00 (0.94-1.00)	RR: 1.00 (0.99-1.01)	1471 (9 studies)	+	+	-	-	Low
Diagnostic accuracy	846 per 1000	17 higher per 1000 (17 lower to 59 more)	RR: 1.02 (0.98-1.07)	1604 (10 studies)	+	+	-	-	Low

¹Population: Patients with a solid pancreatic lesion. Index test: Real-time elastography-endoscopic ultrasound-guided fine-needle aspiration/biopsy/B or Contrast-enhanced harmonic-endoscopic ultrasound-guided fine-needle aspiration/biopsy. Comparator test: Standard Endoscopic ultrasound-guided fine-needle aspiration/biopsy.

EUS-FNA/B: Endoscopic ultrasound-guided fine-needle aspiration/biopsy.

Citation: Rath MM, Anirvan P, Varghese J, Tripathy TP, Patel RK, Panigrahi MK, Giri S. Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis. World J Methodol 2025; 15(3): 97415
URL: https://www.wjgnet.com/2222-0682/full/v15/i3/97415.htm
DOI: https://dx.doi.org/10.5662/wjm.v15.i3.97415