Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis

Table 1 Baseline characteristics of the studies included in the meta-analysis, mean ± SD/median (range/25^th-75^th percentiles)

Ref.	Country	Study design	Arm	Number of patients	Age	Lesion size, in mm	Lesion location (H/U-B/T)	Contrast	Needle	Suction	Number of passes	ROSE
Hou et al[17]	China	Retrospective	CEH-EUS FNA	58	55.1 ± 11.7	38 ± 12	35/23	SonoVue	22-G	-	3.7 ± 0.9	No
			EUS-FNA	105	56.2 ± 12.5	39 ± 8.0	65/40	-			3.6 ± 0.8
Seicean et al[18]	Romania	Prospective, cross-over	CEH-EUS FNA	51	64 (39-83)	35	31/10	SonoVue	22-G	-	2	No
			EUS-FNA					-			2
Sugimoto et al[19]	Japan	RCT	CEH-EUS FNA	20	69.5 ± 10.5	25.0 ± 8.0	13/7	Sonazoid	22-G	DS	1-5	Yes
			EUS-FNA	20	67.1 ± 9.9	26.5 ± 9.2	13/7	-	22-G or 25-G		1-5
Facciorusso et al[20]	Italy	Retrospective	CEH-EUS FNA	103	66 ± 6	32 ± 11	71/32	SonoVue	22-G	DS	2.4 ± 0.6	No
			EUS-FNA	103	66 ± 8	32 ± 10	71/32	-			2.7 ± 0.8
Itonaga et al[21]	Japan	Prospective, cross-over	CEH-EUS FNA	93	72.5 (34–89)	25.2 (12-56)	55/38	Sonazoid	22-G	DS	2.6 (2-5)	No
			EUS-FNA					-
Seicean et al[22]	Romania	RCT, cross-over	CEH-EUS FNA	148	64.5 (62.6 – 66.3)	30 (20.8- 35)	103/45	SonoVue	22-G	-	1	No
			EUS-FNA					-			1
Cho et al[23]	South Korea	RCT	CEH-EUS FNA/B	120	66.3 ± 11.8	30.9 ± 2.1	54/66	SonoVue	19- to 25-G	DS	1-5	No
			EUS-FNA/B	120	68.3 ± 11.9	33.1 ± 16.4	60/60	-			1-5
Gheorghiu et al[24]	Romania	Prospective, cross-over	RTE-EUS FNA	60	66.4 ± 10.0	30 (29.5 -35)	44/16	-	22-G	No	1	No
			EUS-FNA					-			1
Lai et al[25]	Taiwan	Retrospective	CEH-EUS FNB	48	63.6 ± 12.6	29.5 ± 11.5	29/11/8	Sonazoid	22-G	SSP	2.2 ± 0.7	No
			EUS-FNB	85		34.8 ± 18.2	39/36/10	-			3.6 ± 1.2
Kuo et al[26]	Taiwan	RCT	CEH-EUS FNB	59	64.7 ± 11.6	37.5 (28.8-45.9)	30/29	Sonazoid	22-G	No	1-6	Yes
			EUS-FNB	59	64.1 ± 12.6	37.5 (30.6-46.2)	34/25	-			1-6

EUS-FNA/B: Endoscopic ultrasound-guided fine-needle aspiration/biopsy; CEH-EUS-FNA/B: Contrast-enhanced harmonic-EUS-FNA/B; RTE-EUS-FNA/B: Real-time elastography EUS-FNA/B; Lesion location (H/U-B/T): Head or uncinate process-body or tail; RCT: Randomized controlled trial; ROSE: Rapid on-site evaluation; DS: Dry suction; SSP: Slow stylet pull.