Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome

Table 1 Baseline clinical and laboratory characteristics of study participants on pediatric intensive care unit admission (n = 1278), n (%)/median (interquartile range)

Characteristics	Non-survivor (n = 39)	Survivors (n = 1239)	P value
Age (years)	7 (5-10)	8.1 (5.4-10.7)	0.16
Female sex	18 (46)	601 (49)	0.77
Underlying diseases	7 (18)	73 (6)	< 0.01
Day of occurrence of dengue shock since onset of fever (days)	4 (4-5)	5 (4-5)	0.09
Grading of DSS
Compensated DSS	11 (28)	1143 (92)	< 0.001
Decompensated DSS	28 (72)	96 (8)
Severe bleeding	29 (74)	66 (5.3)	< 0.001
Respiratory rate (breaths/min)	30 (24-40)	25 (22-30)	< 0.001
Systolic shock index (bpm/mmHg)	1.47 (1.33-1.88)	1.3 (1.11-1.5)	< 0.01
White blood cell count (× 109/L)	7.15 (3.86-12.9)	4.74 (3.36-6.7)	0.93
Hemoglobin (g/dL)	13.8 (11.5-15.1)	14.9 (13.5-16.1)	0.01
Peak hematocrit (%)	46 (42-52)	48 (45-51)	0.07
Nadir hematocrit (%)	33 (29-34)	38 (35-41)	0.001
Platelet cell count (× 109/L)	25 (14-42.4)	36 (23-55)	0.21
Platelet transfusion	34 (87)	129 (10.4)	< 0.001
Aspartate aminotransferase (IU/L)	2219 (572-4458)	148 (86-314)	< 0.001
Alanine aminotransferase (IU/L)	724 (324-1670)	63 (34-149)	< 0.001
Severe transaminitis	25 (64)	105 (9)	< 0.001
International normalized ratio	2.52 (1.83-3.57)	1.21 (1.1-1.47)	< 0.001
Blood lactate (mmol/L)	7.2 (3.1-13)	2.3 (1.6-3.1)	< 0.001
Serum creatinine (mmol/L)	65 (56-111)	51 (44-59)	0.001
Cumulative fluid infused from referral hospitals and 24 h of PICU admission (mL/kg)	301 (220-393)	133 (104-176)	< 0.001
Ratio of colloid-to-crystalloid infusion	6.0 (1.7-9.1)	0.7 (0-2.0)	< 0.001
Vasoactive inotropic score during first 24 h	60 (40-165)	0 (0-15)	< 0.001
Vasoactive inotropic score > 30	30 (79)	17 (13)	< 0.001

DSS: Dengue shock syndrome; PICU: Pediatric intensive care unit.