Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

Table 3 Duration of seizure activity in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	Mean duration of seizure (seconds)	SEM
Vehicle (control group)	22.00	1.09
Carbamazepine 4 mg/kg	14.37	0.68
Carbamazepine 6 mg/kg	11.63	0.39
Carbamazepine 8 mg/kg	10.33a	0.58
Rosuvastatin 10 mg/kg	23.80	1.14
Rosuvastatin 20 mg/kg	21.13	0.74
Rosuvastatin 30 mg/kg	22.53	0.61
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	10.20a	0.60

^aP value < 0.05 in comparison with control group (Dunn Post hoc analysis).