Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

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Jun 20, 2025 (publication date) through Dec 26, 2024

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Jun 20, 2025; 15(2): 99580
Published online Jun 20, 2025. doi: 10.5662/wjm.v15.i2.99580

Table 1 Tonic hind limb extension in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	THLE present	% with THLE present
Vehicle (control group)	6	100.00%
Carbamazepine 4 mg/kg	0	0.00%^a
Carbamazepine 6 mg/kg	0	0.00%^a
Carbamazepine 8 mg/kg	0	0.00%^a
Rosuvastatin 10 mg/kg	5	83.33%
Rosuvastatin 20 mg/kg	4	66.67%
Rosuvastatin 30 mg/kg	4	66.67%
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	0	0.00%^a

^aP value < 0.05 in comparison with control group (Fischer exact test).

THLE: Tonic hind limb extension.

Citation: Tayal V, Mandal A, Haque M I, Mishra A, Kalra BS, Roy V. Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy. World J Methodol 2025; 15(2): 99580
URL: https://www.wjgnet.com/2222-0682/full/v15/i2/99580.htm
DOI: https://dx.doi.org/10.5662/wjm.v15.i2.99580