Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction

Table 5 Area under the curve analysis for observed hematological-derived ratios regarding death

Variable	Time	AUC/ROC analysis
		AUC (95%CI)	Cut-off	Se	Sp	P value
AISI	T1	0.675 (0.599-0.745)	> 1113.861	64.0	76.6	0.004
	T2	0.690 (0.615-0.759)	> 911.4	68.0	75.9	0.004
CRP/Ly	T1	0.702 (0.448-0.603)	> 4.737	84.0	53.1	< 0.001
	T2	0.718 (0.643-0.784)	> 22.3	72.00	70.34	< 0.001
dNLRT	T1	0.681 (0.606-0.751)	> 2.46	84.0	51.0	0.002
	T2	0.671 (0.595-0.741)	> 4.81	44.0	89.0	0.007
LCR	T1	0.698 (0.623-0.766)	≤ 0.202	84.00	52.45	< 0.001
	T2	0.699 (0.637-0.774)	≤ 0.041	71.00	69.34	< 0.001
LMRT	T1	0.634 (0.557-0.707)	≤ 1.926	64.00	66.90	0.038
	T2	0.638 (0.561-0.710)	≤ 1.952	64.00	69.66	0.033
MLR	T1	0.634 (0.557-0.707)	> 0.509	64.00	66.90	0.039
	T2	0.637 (0.560-0.710)	> 0.509	64.00	69.66	0.033
MNR	T1	0.673 (0.597-0.743)	≤ 0.08	64.00	71.03	0.004
	T2	0.681 (0.649-0.724)	≤ 0.079	60.00	74.28	< 0.001
NLPR	T1	0.664 (0.588-0.735)	> 0.018	80.00	55.17	0.004
	T2	0.757 (0.686-0.819)	> 0.021	68.00	70.34	< 0.001
NLR	T1	0.707 (0.632-0.774)	> 4.076	84.00	51.72	< 0.001
	T2	0.811 (0.727-0.859)	> 4.667	74.00	76.72	< 0.001
NPR	T1	0.598 (0.520-0.672)	> 0.028	72.00	48.97	0.072
	T2	0.657 (0.580-0.728)	> 0.025	76.00	52.41	0.005
PLR	T1	0.676 (0.600-0.745)	> 230.232	52.00	84.14	0.005
	T2	0.719 (0.645-0.785)	> 159.74	72.00	72.41	< 0.001
SII	T1	0.706 (0.631-0.773)	> 1745.18	56.00	82.76	< 0.001
	T2	0.744 (0.671-0.808)	> 1400.466	64.00	81.38	< 0.001
SIRI	T1	0.661 (0.584-0.731)	> 3.907	68.00	66.90	< 0.001
	T2	0.684 (0.608-0.753)	> 4.164	64.00	74.48	0.003

HDR: Hematological-derived ratios; NLR: Neutrophil-to-lymphocyte ratio; dNLR: Derived neutrophil-to-lymphocyte ratio; NPR: Neutrophil-to-platelet ratio; NLPR: neutrophil to lymphocyte and platelet ratio; PLR: Platelet-to-lymphocyte ratio; MNR: Monocyte to neutrophil ratio; MLR: Monocyte/lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; LCR: Lymphocyte to C-reactive protein ratio; CRP/Ly: C-reactive protein-to-lymphocyte ratio; SII: Systemic immune inflammation index; AISI: Aggregate index of systemic inflammation; SIRI: Systemic inflammation response index; T1: Analysis at admission; T2: Analysis after 24 hours; AUC: Area under the curve; ROC: Receiver operating characteristic.