Ensemble for evaluating diagnostic efficacy of non-invasive indices in predicting liver fibrosis in untreated hepatitis C virus population

doi:10.5662/wjm.v14.i3.91058

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (840)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-6) series.

Item

Count

PDF

HTML

664

Figures (1-4)

Tables (1-6)

Sum=798

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=26

Sep 20, 2024 (publication date) through Jul 17, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Methodology

ISSN

2222-0682

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Methodol. Sep 20, 2024; 14(3): 91058
Published online Sep 20, 2024. doi: 10.5662/wjm.v14.i3.91058

Table 2 Biological variables for non-fibrotic, mild fibrotic, moderate fibrotic and severe fibrotic hepatitis C virus cases

Indices	No fibrosis⁰		Mild fibrosis¹		Moderate fibrosis²		Severe fibrosis³		P value
Indices	Median	IQR	Median	IQR	Median	IQR	Median	IQR	P value
Routine investigations
Viral load	112792	56721.5-131470.5	308255	231893.25-424659.75	1050000	696516.5-1334612.5	4956005	3170155.25-9357337	0.000^a
Hb	13.2	11.35-15	13	11.07-14.7	13	10.65-14	12.95	10.95-13.4	0.674
INR	1	1-1.1	1.1	1.0175-1.3	1.1	1-1.185	1.09	1-1.1775	0.478
TSP	6.9	6.55-7.155	6.9	6.6-7.2	7.1	6.65-7.72	7	6.55-7.2	0.683
Albumin	3.9	3.55-4.5	3.8	3.5-4.175	4.1	3.55-4.3	3.85	3.375-4.3	0.849
Bilirubin	0.68	0.4-0.7	0.7	0.5-0.895	0.7	0.4-0.95	0.8	0.475-1	0.488
AST	43	31.5-63	53.5	30.5-92.75	97	70.5-115.5	108.5	62.5-172.5	0.000^a
ALT	50	36-77	60	40.25-93.3	92	56-175.5	106.5	85.25-151	0.030^a
ALP	85	77.5-88	82	78.25-88	102	97.5-131	150	129.5-168	0.000^a
TLC	8800	7700-9450	8050	6750-9075	7200	6600-8500	7200	6500-7725	0.000^a
Plt count	216	158-279.5	195	138.75-235	160	111.5-210	130	102-160.25	0.000^a
Special investigations
Fibronectin	98	89.82-101.25	118	113.4-126.57	147	138.75-154	204.5	188.975-222.25	0.000^a
AAR	0.83	0.64-1.08	0.86	0.71-1.21	0.89	0.724-1.26	1.82	1.159-4.37	0.704
APRI	0.52	0.33-0.69	0.6	0.495-1.84	1.67	0.95-2.291	1.82	1.159-4.37	0.000^a
FIB-4	1	0.63-1.29	1.44	0.98-2.29	2.52	2.04-3.918	3.77	2.68-6.6	0.000^a

⁰Stage 0, n = 25.

¹Stage 1, n = 24.

²Stage 2, n = 25.

³Stage 3, n = 26.

^aStatistically significant values with cut-off for significance set at < 0.05.

AAR: Alanine aminotransferase ratio; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase to platelet ratio index; AST: Aspartate aminotransferase; FIB-4: Fibrosis-4; Hb: Hemoglobin; INR: International normalized ratio; IQR: Inter-quartile range; Plt: Platelet; TLC: Total leukocyte count; TSP: Total serum protein.

Citation: Kaur N, Goyal G, Garg R, Tapasvi C, Demirbaga U. Ensemble for evaluating diagnostic efficacy of non-invasive indices in predicting liver fibrosis in untreated hepatitis C virus population. World J Methodol 2024; 14(3): 91058
URL: https://www.wjgnet.com/2222-0682/full/v14/i3/91058.htm
DOI: https://dx.doi.org/10.5662/wjm.v14.i3.91058