COVID-19 mutations: An overview

doi:10.5662/wjm.v14.i3.89761

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World J Methodol. Sep 20, 2024; 14(3): 89761
Published online Sep 20, 2024. doi: 10.5662/wjm.v14.i3.89761

Table 2 Showing the five variants of concerns and their mutations

WHO label	Pango lineage	GISAID clade	Nextstrain clade	Spike protein substitutions	First detected	WHO date of designation
Alpha	B.1.1.7	GRY	201(V1)	Deletion 69-70, Deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H	United Kingdom	18^th December 2020
Beta	B.1.351	GH/501Y.V2	20H(V2)	D80A, D215G, DeletionL242, DeletionA243, DeletionL244, K417N, E484K, N501Y, D614G, A701V	South Africa	18^th December 2020
Delta	B.1.617.2	G/478K.V1	21A	T19R, T95I, G142D, Deletion156, Deletion157, R158G, L452R, T478K, D614G, P681R and D950N	India	VOI: 4^th April, 2021 VOC: 11^th May, 2021
Gamma	P.1	GR/501Y.V3	20J(V3)	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I	Brazil	11^th January 2021
Omicron	B.1.1.529 lineage	GR/484A	21K	A76V, T95I, Y145del, G339D, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, L212I, S371L, S373P, S375F, K417N. ORF1a: K856R, ORF1a: L2084I, ORF1a: A2710T, ORF1a: T3255I, ORF1a: P3395H, ORF1a: I3758V, ORF1b: P314L, ORF1b: I1566V, and ORF9b: P10S	Botswana and South Africa	26^th November 2021

WHO: World health organization; GISAID: Global initiative on sharing all influenza data; VOI: Variants of interest; VOC: Variants of concern.

Citation: Sarkar M, Madabhavi I. COVID-19 mutations: An overview. World J Methodol 2024; 14(3): 89761
URL: https://www.wjgnet.com/2222-0682/full/v14/i3/89761.htm
DOI: https://dx.doi.org/10.5662/wjm.v14.i3.89761