Compensated liver cirrhosis: Natural course and disease-modifying strategies

Table 1 Factors associated with decompensation of compensated liver cirrhosis

Risk factors for non-acute decompensation	Precipitating factors for acute decompensation
Thick fibrous septa and micronodularity on liver biopsy	Bacterial infection
Persistent liver injury by etiological factor	Active alcoholism
High portal pressure	Gastrointestinal haemorrhage
Systemic inflammation & hemodynamic changes	Consumption of hepatotoxic drug/alternative medicine
Metabolic risk factors: DM, obesity, and dyslipidaemia	Superinfection or flare of viral hepatitis
Genetic risk factors: PNPLA3 G/G genotype	Major surgery and general anaesthesia

DM: Diabetes mellitus; PNPLA3: Patatin-like phospholipase domain-containing protein 3.