Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis

Table 4 Tumor and treatment characteristics, n (%)

	Necrosis		Hemorrhage		Mitotic count		Tumor size		Pcna index		Cell type			Treatment
Ref.	Yes	No	Yes	No					≤ 10%	> 10%	Epithelioid	Spindle	Mixed	Surgery	Surgery type	Chemotherapy	Chemotherapy type
Chen et al[22]	23 (37)	39 (63)	45 (72.6)	17 (27.4)	36 (58) < 2/10 HPF	26 (42) ≥ 2/10 HPF	32 (51.6) < 5 cm	30 (48.4) ≥ 5 cm	32 (51.6)	30 (48.4)	N/A	N/A	N/A	Yes	Subtotal gastrectomy, complete tumor resection or segmental enterectomy	Yes (some of them)	See comments
Imamura et al[8]	N/A	N/A	N/A	N/A	55 (57.9) < 5/50 HPF	40 (42.1) ≥ 5/50 HPF	39 (41.05) < 5 cm	56 (58.95) ≥ 5 cm	N/A	N/A	1 (1.05)	92 (96.85)	2 (2.1)	Yes	Resection with negative margins	N/A	N/A
Takahashi et al[23]	N/A	N/A	N/A	N/A	33 (62.2) < 3/50 HPF	20 (37.7) ≥ 3/50 HPF	21 (39.6) ≤ 3 cm	32 (60.3) > 3 cm	N/A	N/A	N/A	N/A	N/A	Yes	Surgical resection	N/A	N/A
Waengertner et al[24]	N/A	N/A	N/A	N/A	N/A	N/A	N/A, varies from 0.5 to 25 cm (median 4.8 cm)		N/A	N/A	N/A	57 (72.2%)	N/A	N/A	N/A	Yes	Adjuvant therapy with tyrosine kinase inhibitors (400mg/daily) for no longer than 3 months
Wang et al[9]	N/A	N/A	N/A	N/A	45 (66.2) < 2/10 HPF	23 (33.8) ≥ 2/10 HPF	24 (35.3) ≤ 5 cm	44 (64.7) > 5 cm	N/A	N/A	N/A	N/A	N/A	Yes	N/A	No	No
Zhao et al[25]	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	28 (22.58)	73 (58.87)	23 (18.55)	Yes	Only biopsy, palliative resection, radical resection	Yes	Postoperative

N/A: Not applicable.