Hemostatic system and COVID-19 crosstalk: A review of the available evidence

Table 3 Frequency of venous thromboembolic complications in coronavirus disease 2019 patients

Ref.	Proportion	Cumulative incidence	Median follow-up	Patients
Cui et al[59]	20/81 (25%)	NR	NR	ICU patients
Klok et al[60]	68/184 (37%)	57% or 49% adjusted for competing risk of death	14 d	ICU patients only.19 PE were limited to subsegmental arteries.65/68 venous events were PE (95.6%)
Poissy et al[61]	VTE 22.2% of 54 ICU admitted
Helms et al[44]	27/150 (18%)	NR	NR	ICU patients with ARDS 25/27 events were PE (92.5%)
Poissy et al[61]	PE only 22/107 (20.6%)	20.4% calculated at ICU day 15	6 d	ICU only
Middeldorp et al[63]	Venous thromboembolism 39% of COVID-19 ICU cases 74 patients
Llitjos et al[64]	DVT: 18/26 (69%); PE: 6/26 (23%)	NR	NR	ICU patients. Systematic ultrasound screening
Léonard-Lorant et al[183]	PE only 32/106 (30%)	NR	NR	24/32 (75%) PE-positive patients were in the ICU
Grillet et al[184]	PE only 23/100 (23%)	NR	NR	Ward: 6/61 (9.8%); ICU: 17/39 (43.6%)
Middeldorp et al[63]	33/198 (17%)	15% at 7 d; 34% at 14 d	5 d	Ward: 4/123 (3.3%); ICU: 35/75 (47%); 11 (5.4%) clots detected on screening 11/33 events were PE (33%)
Lodigiani et al[185]	16/362 (4.4%)	21% (time not reported)	10 d	ICU 4/48(8.3%); Ward 12/314 (3.8%)
Thomas et al[186]	6/63 (9%)	27%	8 d	ICU patients
Cattaneo et al[108]	DVT only 0/388 (0%)	NR	NR	Non-ICU Ward 64 patients had screening ultrasound. All negative

DVT: Deep vein thrombosis; ICU: Intensive care unit; NR: Not reported; PE: Pulmonary embolism.