COVID-19 disease and autoimmune disorders: A mutual pathway

Table 3 Differences between the classic Kawasaki disease and Kawasaki disease - coronavirus disease 2019

	Classic KD	KD-COVID-19
Age	Children < 5 yr of age	Older age
General condition	Less ill than in KD-COVID-19	More severely ill
Gastrointestinal & meningeal signs	Less common	More common
CBC	Leucocytosis, anemia, & thrombocytosis. Thrombocytopenia may occur	Leukopenia with marked lymphopenia, thrombocytopenia
Ferritin	Increased	Markedly increased
Incidence of myocarditis	Subclinical myocarditis is nearly present in all patients. However, clinically evident myocarditis is uncommon.	Very high, up to 60.4% in patients with KD-like multisystemic disease.
Response to IV gamma globulins	Well-responding	Resistance to IVIG therapy is common.
Adjunct steroids	May be needed	Usually needed

COVID-19: Coronavirus disease 2019; CBC: blood cell count; KD: Kawasaki disease; IVIG: Intravenous immunoglobulin.