Evidence based review of management of cardiorenal syndrome type 1

Table 2 Changes in clinical parameters of the included studies

Intervention	Clinical parameters evaluated
	Ref.	Creatinine (mg/dL)		Change in BUN (mg/dL)		Cystatin C (mg/L)		Weight loss (kg)	Cumulative urine volume (mL)
		Baseline	Mean changes	Baseline	Mean changes	Baseline	Mean changes	Mean changes
Nesiritide	Owan et al[10], 2008	1.85 ± 0.71	0.04 ± 0.44	44.8 ± 23.3	-1.3 ± 12.8	NA	NA	-2.75 ± 3.27	NA
	Owan et al[10], 2008 (placebo)	1.65 ± 0.42	0.09 ± 0.25	38.3 ± 16.6	2.4 ± 6.8	NA	NA	-4.25 ± 3.42	NA
	Chen et al[13], 2013	1.65	0.02	NA	NA	1.66	0.07	NA	8574
	Chen et al[13], 2013 (placebo)	1.70	0.02	NA	NA	1.86	0.11	NA	8296

BUN: Blood urea nitrogen; NA: Not available.