Molecular diagnosis in cat allergy

Table 1 Characteristics of cat molecular allergens[7-11] mentioned in the World Health Organization/International Union of Immunological Societies database[4]

Allergen	Biochemical designation	Source of exposure	MW in kDa
Fel d 11,2	Secretoglobin4	Saliva, dander	38
Fel d 21,3	Serum albumin	Dander, serum, urine	69
Fel d 3	Cystatin5	Dander	11
Fel d 41,2	Lipocalin5	Saliva	22
Fel d 5	Immunoglobulin A4	Saliva, serum	400
Fel d 6	Immunoglobulin M4	Saliva, serum	800-1000
Fel d 72	Lipocalin, von Ebner gland protein	Saliva	17.5
Fel d 8	Latherin-like protein	Saliva	24

The World Health Organization/International Union of Immunological Societies is commonly known by its acronym, WHO/IUIS. Fel d 1, Fel d 2, Fel d 4 and Fel d 7 allergens are available in commercial immunoglobulin E immunoassays:

¹Available in singleplex immunoassays as recombinant allergen.

²Available in multiplex immunoassays as recombinant allergen.

³Available in multiplex immunoassays as native purified component.

⁴Presence of glycosylation.

⁵Glycosylation deduced from sequence analysis. MW: Molecular weight.