Molecular diagnosis in cat allergy

doi:10.5662/wjm.v11.i3.46

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May 20, 2021 (publication date) through Jul 5, 2024

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. May 20, 2021; 11(3): 46-60
Published online May 20, 2021. doi: 10.5662/wjm.v11.i3.46

Table 1 Characteristics of cat molecular allergens[7-11] mentioned in the World Health Organization/International Union of Immunological Societies database[4]

Allergen	Biochemical designation	Source of exposure	MW in kDa
Fel d 1¹^,²	Secretoglobin⁴	Saliva, dander	38
Fel d 2¹^,³	Serum albumin	Dander, serum, urine	69
Fel d 3	Cystatin⁵	Dander	11
Fel d 4¹^,²	Lipocalin⁵	Saliva	22
Fel d 5	Immunoglobulin A⁴	Saliva, serum	400
Fel d 6	Immunoglobulin M⁴	Saliva, serum	800-1000
Fel d 7²	Lipocalin, von Ebner gland protein	Saliva	17.5
Fel d 8	Latherin-like protein	Saliva	24

The World Health Organization/International Union of Immunological Societies is commonly known by its acronym, WHO/IUIS. Fel d 1, Fel d 2, Fel d 4 and Fel d 7 allergens are available in commercial immunoglobulin E immunoassays:

¹Available in singleplex immunoassays as recombinant allergen.

²Available in multiplex immunoassays as recombinant allergen.

³Available in multiplex immunoassays as native purified component.

⁴Presence of glycosylation.

⁵Glycosylation deduced from sequence analysis. MW: Molecular weight.

Citation: Popescu FD, Ganea CS, Panaitescu C, Vieru M. Molecular diagnosis in cat allergy. World J Methodol 2021; 11(3): 46-60
URL: https://www.wjgnet.com/2222-0682/full/v11/i3/46.htm
DOI: https://dx.doi.org/10.5662/wjm.v11.i3.46