Potential therapeutic targets from genetic and epigenetic approaches for asthma

Table 3 The microRNAs and their potential roles in asthma

miRNA	Possible function roles in asthma	Ref.
miR-1	Targeting Mpl to regulate TH2 inflammation and P-selectin in lung endothelium	[109]
miR-126a	Regulating TH2 inflammation, airway hyper-responsiveness, eosinophil recruitment	[110]
miR-221	Mediator IL-6 proliferation in airway smooth muscle	[42]
miR-146a	NF-κB dependent gene, control toll-like receptors and cytokine signalling	[111]
miR-146b	NF-κB dependent gene, control toll-like receptors and cytokine signalling	[111]
miR-150	Down-regulated transcription factor c-Myb to control lymphocyte development	[112]
miR-155	Targeting c-Maf to promote TH2 cells to generate IL-4, IL-5 and IL-10	[115,116]

IL: Interleukin; NF-κB: Nuclear factor kappa-B.