Potential therapeutic targets from genetic and epigenetic approaches for asthma

Table 1 The potential genetic therapeutic targets in airway epithelium for asthma

Genes	Chromosome location	Phenotypes	Identifying methods	Possible pathways related to asthma	Ref.
DPP10	2	Asthma	GWAS/PC	Unknown; Kv4 ion channel complex	[8,20]
TSLP	5	Asthma	GWAS	Airway remodelling; promoting TH2 inflammation	[23,30]
CDHR3	7	Asthma	GWAS	Epithelial polarity; cells interaction and differentiation	[26]
SEMA3D	7	Asthma	GWAS	Airway remodelling; angiogenesis	[27]
SMAD3	15	Asthma	GWAS	Transcriptional modulator; TGFβ pathway	[15]
ORMDL3	17	Asthma	GWAS	Sphingolipid metabolism, ER stress response	[14,15,21,23,25,26]
GSDMB	17	Asthma	GWAS	Epithelium cell growth	[14,15,21,23,25,26]
GSDMA	17	Asthma	GWAS	Cell proliferation	[14,15,21,23,25,26]

PC: Positional cloning; GWAS: Genome-wide association study; TGFβ: Transforming growth factor-beta; ER: Endoplasmic reticulum.