Assessment of platelet function: Laboratory and point-of-care methods

Table 3 Major platelet function tests: Clinical value

Platelet tests	Clinical value	Ref.
Light transmission platelet aggregation	Assessment of: (1) idiopathic bleeding behavior (primary hemostasis defective); (2) residual platelet reactivity of patients on antiplatelet treatment to stratify risk of ischemic events; (3) detection of VWD (RIPA test); (4) diagnostic for platelet surface glycoprotein defects.	Moffat et al[34] Hayward et al[41] Gadisseur et al[43] Breet et al[44] Buonamici et al[45] Paniccia et al[51,65] Gum et al[63] Rechner[107]
Whole blood platelet aggregation	Assessment of: (1) idiopathic bleeding behavior (primary hemostasis defective); (2) residual platelet reactivity of patients on antiplatelet treatment to stratify risk of ischemic events; (3) acquired bleeding risk: antiplatelet therapy, surgical coagulopathy; (4) detection of VWD (RIPA test); (5) diagnostic for HIT.	Paniccia et al[72] Paniccia et al[73] Sibbing et al[74] Sibbing et al[75] Würtz et al[77] Bolliger et al[78] Morel-Kopp et al[79] Ranucci et al[81] Görlinger et al[84]
PFA-100 Innovance PFA-200	Assessment of: (1) idiopathic bleeding behavior (primary hemostasis defective); (2) detection of VWD; (3) acquired bleeding risk: anti-plt therapy, surgical coagulopathy; (4) thrombotic risk also in relation to potential failure of anti-plt therapy; (5) platelet function in pregnancy, kidney or liver disease.	Hayward et al[25] Favaloro[94] Koessler et al[92] Marcucci et al[103] Reny et al[104] Crescente et al[105] Raman et al[108] Cammerer et al[109] Chauleur et al[113]
VerifyNow system	Assessment of: (1) residual platelet reactivity of patients on antiplatelet treatment to stratify risk of ischemic events; (2) low platelet reactivity of patients on antiplatelet treatment to stratify risk of bleeding events (scarce clinical data).	Breet et al[44] Paniccia et al[51,65] Tantry et al[116] Marcucci et al[119] Price et al[120] Angiolillo et al[121]

HIT: Heparin-Induced Thrombocytopenia; plt: Platelet; RIPA: Ristocetin-Induced Platelet Aggregation; VWD: Von Willebrand Disease.