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World J Transl Med. Dec 12, 2013; 2(3): 32-35
Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.32
Published online Dec 12, 2013. doi: 10.5528/wjtm.v2.i3.32
Figure 2 Activation and pH-dependent cyclization of dipeptidyl boroLeu.
A tumor-specific protease recognition sequence (TSPRS) is attached to the N-terminus of the dipeptidyl boroLeu. The dipeptidyl boroLeu is released in its active form by a tumor-specific protease and undergoes a pH-dependent cyclization equilibrium. In the present study, low pH = 2 and mid pH = 7.6.
- Citation: Micale N. Peptide-based boronates: How to achieve tissue specificity in anticancer therapy. World J Transl Med 2013; 2(3): 32-35
- URL: https://www.wjgnet.com/2220-6132/full/v2/i3/32.htm
- DOI: https://dx.doi.org/10.5528/wjtm.v2.i3.32