Cell-free mitochondrial DNA quantification in ischemic stroke patients for non-invasive and real-time monitoring of disease status

Figure 3 Intergroup differences in cell-free mitochondrial DNA concentrations. A-C: Changes in relative expression levels of NADH-ubiquinone oxidoreductase chain 1 (ND1) compared to 12S expression between control individuals and patients at disease onset, 24 h of treatment, and 72 h of treatment; D-F: Receiver operating characteristic plot showing the diagnostic significance of ND1 relative expression levels in patients at disease onset, 24 h of treatment, and 72 h of treatment. ^bP < 0.001; ^cP < 0.0001. AUC: Area under curve; cf-mtDNA: Cell-free mitochondrial DNA; ROC: Receiver operating characteristic.