Current progress and emerging technologies for generating extrapancreatic functional insulin-producing cells

Figure 2 Representation of encapsulation technology for glycemic control in diabetes. A: Schematic representation showing the applicability of microencapsulation of intermediate, progenitor cells derived from human hepatic progenitor cells under hyperglycemic microenvironment post intraperitoenal transplantation into diabetic mice. The strategy demonstrated the long-term maintenance of blood glucose homeostasis in diabetic mice; B: The microencapsulation strategy overcomes on immunological barriers and allows efficient supply of oxygen and nutrients to encapsulated cells in 3D-environment which can control the hyperglycemia in human from ectopic site. InPCs: Insulin producing cells; HPC: Hepatic progenitor cells.