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Copyright ©The Author(s) 2022.
World J Transl Med. Jun 26, 2022; 10(1): 1-13
Published online Jun 26, 2022. doi: 10.5528/wjtm.v10.i1.1
Table 2 The pros and cons of different transplantation sites used for cell delivery in diabetic condition
Transplantation site
Pros
Cons
Ref.
Liver Ease of transplant, Portal insulin deliveryPortal hypertension, bleeding, portal vein thrombosis, inflammation, portal circulation Kim et al[77], 2010
Kidney subcapsuleGraft retrieval, immunological toleranceNot ideal site, invasive procedure, graft tissue oxygen tensionReece-Smith et al[78], 1981
SpleenGood vascular supply, portal vein insulin deliveryRich in lymphocytes, risk of bleedingGray[79], 1990; Alderson et al[80], 1984
PancreasHome of islets, ideal oxygen tensionAutoimmune destruction, invasive procedureStagner et al[81], 2008
Omental pouchHigh vascular density, neoangiogenesis, good blood supply, impure islets can be implantedLarge graft unstable, islet cells estimation is empiricalGustavson et al[82], 2005
Gastro intestinal wallEase of accessibility, portal vein delivery of insulinThickening of gastric walls after islet cells transplantationWszola et al[83], 2009
Bone marrowEase of accessibility, no graft rejectionConserved differentiation into α and β cellsSalazar-Bañuelos et al[84], 2008; Cantarelli et al[85], 2009