Complement activation and long-term graft function in ABO-incompatible kidney transplantation

Table 1 Patient and donor characteristics

		ABO-incompatible (n = 27)	ABO-compatible (n = 108)	P value
Patient and donor characteristics
Recipient age (yr)		51.6 ± 12.3	51.7 ± 11.6	0.95
Donor age (yr)		53.6 ± 12.1	52.7 ± 12.4	0.73
Recipient gender (% male)		63	63	1.00
Donor gender (% male)		63	44	0.07
Related/unrelated donors (% related)		26	51	0.02
Donor MDRD (mL/min/1.73m2)		96.6 ± 20.5	93.3 ± 18.4	0.42
HLA mismatches (A/B/DR)		3.5 ± 1.6	3.2 ± 1.7	0.48
Mean follow-up patient (yr)		3.7 ± 1.7	3.7 ± 1.6	0.98
Underlying renal disease				0.57
	Glomerulonephritis, (%)	30	27
	Hypertensive disease, (%)	7	18
	Diabetic nephropathy, (%)	4	7
	Cystic kidney disease, (%)	33	19
	Urological disease, (%)	7	8
	Other, (%)	19	21
Blood type combination
	A→O, (%)	59
	B→O, (%)	15
	AB → O, (%)	0
	B →A, (%)	11
	A→ B, (%)	7
	AB→ A, (%)	4
	AB → B, (%)	4
Median pre-treatment IgG anti-A/B titer		1:64 (1:6-1:128)
Median pre-treatment IgM anti-A/B titer		1:8 (1:2-1:28)
Panel reactive antibodies (% positive)		9	7	0.60
Previous renal replacement therapy
First transplantation (%)		89	94	0.30
Pre-emptive transplantation (%)		44	53	0.44
Non pre-emptive (%)		56	47	0.83
	Haemodialysis (%)	34	26
	Peritoneal dialysis (%)	22	21
Months on dialysis		22 (9-26)	16 (11-27)	0.41
Ischemia times
Cold ischemia time (min)		161 ± 84	155 ± 59	0.49
Second warm ischemia time (min)		41 ± 27	40 ± 22	0.77
Delayed graft function (%)		8	4	0.37

All values as percentages, mean ± standard deviation or median and interquartile range. P values calculated with t-test, Mann-Whitney U test or chi-square test where applicable. Panel reactive antibodies > 8% were considered positive. HLA: Human leukocyte antigen; IgG: Immunoglobulin G; IgM: Immunoglobulin M; MDRD: Modification of diet in renal disease.