Tesevatinib ameliorates progression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease

Table 1 BPK summary data

	WT PN-21 Sham n = 22	WT PN-21 VEH n = 10	WT PN-21 TSV 7.5 n = 10	WT PN-21 TSV 15 n = 10	BPK PN-21 Sham n = 17	BPK PN-21 VEH n = 12	BPK PN-21 TSV 7.5 n = 10	BPK PN-21 TSV 15 n = 14
BW (g)	10.31 ± 0.55	10.76 ± 0.72	10.57 ± 0.80	10.10 ± 0.29	10.46 ± 0.60	10.29 ± 0.45	10.50 ± 0.96	10.11 ± 0.50
TKW (g)	0.15 ± 0.01	0.16 ± 0.02	0.141 ± 0.02	0.13 ± 0.01	2.03 ± 0.28	2.01 ± 0.22	1.59 ± 0.19e	1.21 ± 0.09f,e
KW/BW (%)	1.41 ± 0.10	1.50 ± 0.12	1.33 ± 0.08	1.25 ± 0.09	19.32 ± 1.71	19.57 ± 1.62	15.12 ± 1.1e	11.96 ± 1.22f,e
CI	NA	NA	NA	NA	4.7 ± 0.50	4.8 ± 0.42	3.6 ± 0.52e	2.50 ± 0.35f,e
BUN (mg/dL)	19.25 ± 1.14	21.20 ± 1.99	18.60 ± 2.07	19.40 ± 1.5	108.3 ± 17.8	112 ± 23.3	63.6 ± 20.3e	40.9 ± 13.7d,e
Cr (mg/dL)	0.24 ± 0.05	0.29 ± 0.06	0.24 ± 0.05	0.28 ± 0.06	0.55 ± 0.14	0.58 ± 0.10	0.41 ± 0.1b	0.28 ± 0.07c,e
12 h UCA	1043 ± 35	1065 ± 52	1026 ± 39	1024 ± 27	465 ± 83	460 ± 92	581 ± 67a	786 ± 185.2d,e
BDE	NA	NA	NA	NA	4.8 ± 0.4	4.5 ± 0.5	3.70 ± 0.4b	2.8 ± 0.4d,e

^aP < 0.05,

^bP < 0.01,

^eP < 0.001 vs untreated (Sham) BPK;

^cP < 0.05,

^dP < 0.01,

^fP < 0.001 vs BPK TSV treatment at 7.5. CI: Cystic index; UCA: Urinary concentration ability at 12 h; BDE: Biliary ductal ectasia; KW/BW: Kidney weight to body weight; NA: Not applicable; TKW: Total kidney weight.