Application of established pathophysiologic processes brings greater clarity to diagnosis and treatment of hyponatremia

Figure 4 Illustrating how FEurate progressively decreases from an increased rate of 26. 2% to a normal of 8% as serum sodium increases to a normal of 138 mEq/L in syndrome of inappropriate anti-diuretic hormone. Normalization of serum sodium did not occur after receiving large volumes of isotonic saline and was possible by using 1.5% hypertonic saline after receiving volumes of isotonic saline. The increase in serum sodium from 131 to 135 mEq/L occurred when he was on very large salt supplementation. This figure also confirms saline does not increase FEurate. Printed with permission, Ref. [31].