Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?

Table 2 Baseline demographic of cohort that had overhydration > 2 L

Sub-group: Patients with severe OH
Number	66
Age1	60.1 (51.1-71.1)
Male (%)	44 (67%)
Diabetes mellitus (%)	27 (41%)
Assessed as suitable for transplantation (%)	26 (39%)
Dialysis vintage (mo)1	1.79 (0.5-32.1)
Body composition measurements:
Baseline OH (L)1	2.7 (2.3-3.7)
OH over 6 mo (L/6 mo)1	-0.7 (-0.3--1.5)
Baseline FTM (kg)1	23.6 (17.3-28.9)
FTM over 6 mo (kg)1	2.3 (0.1-3.7)3
Baseline LTM (kg)1	37.2 (29.6-44.6)
LTM over 6 mo (kg)1	-1.5 (-4.5-1.7)2
Number of readings	7.4 (0.4)
Cardiac troponin T measurements (ng/L)
Baseline cTnT1	60 (37-100)
Final cTnT1	71 (37-115)
Number of readings	3.4 (0.2)
Ethnicity: n (%)
Whites	26 (39%)
Blacks	14 (21%)
Asians	23 (35%)
Others	3 (5%)
Cause of renal failure: n (%)
Unknown	15 (23%)
GN	9 (14%)
Cancer/trauma	2 (3%)
Congenital/familial	2 (3%)
Diabetes	23 (35%)
Hypertension	6 (9%)
APKD	0 (0%)
TIN/chronic pyelonephritis	9 (14%)
Blood results
Baseline log (CRP) (mg/L)	0.67 (0.08)4
Time average log (CRP) over 6 mo (mg/L)	0.73 (0.08)4
Baseline albumin (g/L)	36.4 (0.6)4
Time average albumin over 6 mo (g/L)	36.0 (0.6)4
Baseline haemoglobin (g/dL)	10.5 (0.2)4
Time average haemoglobin over 6 mo (g/dL)	10.6 (0.2)4

Values represent mean (SEM) or number (%) unless denoted by¹ (values shown are median, interquartile ranges).

²P < 0.05 by Wilcoxon Signed Rank Test to determine if Median is ≠ 0;

³P < 0.0001 by Wilcoxon Signed Rank Test to determine if Median is ≠ 0;

⁴There were no significant correlation with OH by Pearson r correlation. OH denotes the “overhydration”, FTM denotes fat tissue mass and LTM denotes lean tissue mass from the body composition monitor. GN: Glomerulonephritis; APKD: Adult polycystic kidney disease; TIN: Tubular-interstitial nephritis; OH: Overhydration.