Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN

Table 1 Classification of glomerulonephritis

Pathogenetic type	Specific disease entity	Pattern of injury: Focal or diffuse	Score or class
Immune-complex GN	IgA nephropathy, IgA vasculitis, lupus nephritis,	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing or multiple	Oxford/MEST scores for IgA nephropathy
	infection-related GN, fibrillary GN with polyclonal Ig deposits		ISN/RPS class for lupus nephritis
Pauci-immune GN	MPO-ANCA GN,	Necrotizing, crescentic, sclerosing, or multiple	Focal, crescentic, mixed, or sclerosing class (Berden/EUVAS class)
	proteinase 3-ANCA GN,
	ANCA-negative GN
Anti-GBM GN	Anti-GBM GN	Necrotizing, crescentic, sclerosing, or mixed
Monoclonal Ig GN	Monoclonal Ig deposition disease, proliferative GN with monoclonal Ig deposits,	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing or multiple
	immunotactoid glomerulopathy, fibrillary GN with monoclonal Ig deposits
C3 glomerulopathy	C3 GN, dense deposit disease	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing or multiple

GN: Glomerulonephritis; MEST: Mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy; ISN/RPS: International Society of Nephrology/Renal Pathology Society; MPO: Myeloperoxidase antibodies; ANCA: Antineutrophil cytoplasmic antibodies; EUVAS: European vasculitis study group; GBM: Glomerular basement membrane.