C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria

Table 4 Assessment of tubulointerstitial injury in the experimental groups

Group	n	TEC height	TEC diameter	Protein cast/field	Interstitial ED-1/field
Control	9	82.3 ± 1.7	253.0 ± 3.7	0	9.4 ± 0.5
		(83.3, 78.0-87.0)	(256.6, 241.7-259.0)		(9.3, 8.4-10.6)
PON d 2 C6+	6	70.9 ± 5.21	312.1 ± 13.91	-	20.9 ± 1.61
		(69.4, 59.5-79.6)	(311.8, 279.4-343.4)		(20.1, 17.3-25.5)
PON d 2 C6-	5	76.6 ± 2.81	300.8 ± 8.21	-	14.5 ± 4.0
		(76.1, 66.6-80.6)	(308.7, 292.7-316.6)		(11.3, 9.3-17.6)
PON d 4 C6+	6	68.0 ± 2.31	309.0 ± 11.11	2.9 ± 0.5	29.6 ± 2.312
		(68.3, 60.8-71.5)	(296.8, 291.1-341.1)	(3.4, 2.8-3.7)	(28.3, 25.4-38.2)
PON d 4 C6-	6	67.8 ± 3.81	303.2 ± 12.61	2.2 ± 0.6	21.0 ± 1.81
		(69.3, 61.1-75.4)	(313.0, 275.7-324.2)	(1.5, 1.1-3.4)	(20.9, 16.7-23.9)
PON d 8 C6+	8	74.7 ± 2.712	304.0 ± 9.21	1.1 ± 0.33	73.5 ± 6.712
		(76.2, 71.0-78.9)	(295.5, 280.4-319.1)	(0.7, 0.5-1.4)	(78.0, 59.2-85.7)
PON d 8 C6-	9	70.0 ± 2.91	298.0 ± 3.81	1.5 ± 0.5	56.1 ± 7.81
		(67.7, 63.3-75.3)	(298.6, 289.8-308.1)	(1.2, 0.5-2.3)	(56.7, 38.9-80.1)

Data are expressed as mean ± SEM. The units for TEC height and TEC diameter are in arbitrary units.

¹P < 0.05 compared to control (median, Inter-quartile range);

²P < 0.05 when compared to PON day 2, C6⁺;

³P < 0.05 compared to PON day 4, C6⁺. PON: Protein-overload nephropathy; TEC: Tubular epithelial cell.