Matrix metalloproteinase-2 as a superior biomarker for peritoneal deterioration in peritoneal dialysis

Table 5 Test performance of effluent biomarkers cut-off levels to distinguish the high category of peritoneal equilibration test

Biomarkers	Cut-off level	Sensitivity (95%CI)	Specificity (95%CI)	AUC
MMP-2-	214 ng/mL	0.95 (0.86 to 1.00)	0.79 (0.74 to 0.85)	0.90
	219 ng/mL	0.86 (0.71 to 1.00)	0.81 (0.76 to 0.86)
	228 ng/mL	0.81 (0.62 to 0.95)	0.84 (0.79 to 0.89)
	238 ng/mL	0.76 (0.57 to 0.95)	0.87 (0.82 to 0.91)
IL-6	16.8 pg/mL	0.81 (0.62 to 0.95)	0.60 (0.53 to 0.67)	0.78
	19.3 pg/mL	0.76 (0.57 to 0.90)	0.65 (0.58 to 0.73)
	20.0 pg/mL	0.71 (0.52 to 0.90)	0.66 (0.60 to 0.73)
	24.8 pg/mL	0.67 (0.48 to 0.86)	0.75 (0.66 to 0.79)
Hyaluronan	94.5 ng/mL	0.81 (0.62 to 0.95)	0.47 (0.41 to 0.54)	0.62
	101.5 ng/mL	0.71 (0.52 to 0.90)	0.51 (0.44 to 0.58)
	108.0 ng/mL	0.67 (0.48 to 0.86)	0.52 (0.45 to 0.58)
	115.0 ng/mL	0.62 (0.43 to 0.81)	0.53 (0.46 to 0.53)
CA125	3.85 U/mL	0.81 (0.62 to 0.95)	0.23 (0.17 to 0.29)	0.51
	4.45 U/mL	0.71 (0.52 to 0.90)	0.30 (0.23 to 0.37)
	6.55 U/mL	0.62 (0.43 to 0.81)	0.50 (0.43 to 0.57)
	7.05 U/mL	0.52 (0.33 to 0.71)	0.53 (0.46 to 0.59)

AUC: Area under curve; MMP-2: Matrix metalloproteinase-2; IL-6: Interleukin-6; CA125: Cancer antigen 125.