Adult stem cells as a tool for kidney regeneration

Table 3 Effects of adipose tissue-derived mesenchymal stem cells on renal tissue repair

Origin of stem cells	Experimental model	Effects	References
Rat	I/R injury	Recovery of renal function	Chen et al[40]
		Reduction in oxidative stress
Human	Cisplatin-induced AKI	Recovery of renal function	Kim et al[41]
		Conditioned medium was effective
Human	Folic acid-induced AKI	Recovery of renal function	Katsuno et al[42]
		HGF and VEGF production
Rat	Anti-GBM disease	Reduced renal injury and proteinuria	Furuhashi et al[43]
		Conversion of macrophages to immunoregulatory cells
Swine	Renal artery stenosis	Recovery of renal function	Eirin et al[44]
		Improved angiogenesis
		Increased production of VEGF and bFGF
Swine	Renal artery stenosis	Recovery of renal function	Zhu et al[45]
		Improved angiogenesis
		Decreased oxidative stress
Swine	Renal artery stenosis	Recovery of renal function	Ebrahimi et al[46]
		Improved angiogenesis
		Increased production of VEGF
Mouse	Renal fibrosis (unilateral clamping of the renal pedicle)	Recovery of renal function	Donizetti-Oliveira et al[47]
		Reduced fibrosis
		Decreased expression of IL6 and TNF-α

I/R: Ischemia reperfusion; AKI: Acute kidney injury; GBM: Glomerular basement membrane; HGF: Hepatocyte growth factor; VEGF: Vascular endothelial growth factor; bFGF: Basic fibroblast growth factor; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-α.