Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment

Figure 3 Effects of 3% hypertonic saline on plasma concentrations of renin (A), angiotensin II (B), aldosterone (C) and arginine vasopressin (D) in 23 healthy subjects pre-treated with bendroflumethiazide, amiloride or placebo. A-C: There was a significant difference between PRC, p-AngII and p-Aldo plasma levels throughout the study day. Values are means ± SEM. One-way ANOVA was used to test for differences between treatments; D: P-AVP increased significantly at 150 min with a borderline significant difference between treatments (^aP = 0.048). Values are medians with upper and lower limits. Friedman’s test was used to test for differences between treatments. BFTZ: Bendroflumethiazide; PRC: Plasma renin concentration.