Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction

Figure 5 Pharmacodynamics of anti-infective drugs. The pharmacokinetics and the concentration curves are equal in both diagrams. Also the concentration producing the half-maximum effect is the same but the Hill coefficient is different. A: Concentration-dependent effect: With a Hill coefficient of H = 1.0, the calculated peak effect is only 60% and far from the ceiling effect CE₉₅. Thus, the concentration-dependent effect could be strengthened by increasing the dose; B: Time-dependent effect: With a Hill coefficient of H = 4.0, the calculated trough effect falls below the threshold concentration CE₀₅ at the second part of the administration interval. Thus, the time-dependent effect could be strengthened by dosing more frequently.