Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction

Figure 4 Pharmacodynamics. The threshold concentration CE₀₅ produces 5% and the ceiling concentration CE₉₅ produces 95% of the maximum effect. With a Hill coefficient of H = 1.0, the concentration is CE₀₅ = 0.5 units and the CE₉₅ = 190 units whereas for a higher Hill coefficient of H = 4.0, the threshold is high with CE₀₅ = 6.0 units but the ceiling is low with CE₉₅ = 21 units.