Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction

Figure 3 It is most practical to keep the peak concentration constant when the drug dose is adjusted to impaired kidney function[9]. With the eliminated fraction rule (Dettli 3), any dose and any interval can be estimated and selected. The Kunin rule is a special case of the Dettli rule 3 for the condition C_trough = 1/2 C_peak. With the Kunin rule and the Dettli rule 3, the area AUC is higher than under conditions with normal kidney function.