Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction

Figure 2 Dettli rules 1 and 2 for drug dose adjustment in kidney dysfunction. Dettli rule 1 leads to higher trough concentrations but lower peaks. To obtain an immediate antimicrobial effect, a loading dose must be given. With Dettli rules 1 and 2, the area under the curve AUC remains constant.