Complement involvement in kidney diseases: From physiopathology to therapeutical targeting

doi:10.5527/wjn.v4.i2.169

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. May 6, 2015; 4(2): 169-184
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.169

Table 1 Representative abnormalities in complement leading to renal disease

Components/related molecules	Diseases
Complement C3	C3 glomerulopathy (DDD), aHUS
Factor H	C3 glomerulopathy (DDD/C3GN), aHUS
Factor I	C3 glomerulopathy (C3GN), aHUS
MCP	aHUS
Factor B	aHUS
CFHR5	Familial C3 glomerulopathy (CFHR5 nepropathy)
CFHR3-1	Familial C3 glomerulopathy
CFHR1/3	IgA nephropathy, aHUS
Factor B autoantibody	C3 glomerulopathy (DDD)
Factor H autoantibody	C3 glomerulopathy (DDD/C3GN)
Bb (activated factor B)	HUS, ANCA-associated vasculitis
C3Nef	C3 glomerulopathy (DDD, C3GN)
Soluble C5b-9	HUS, TTP, ANCA-associated vasculitis
C3a	ANCA-associated vasculitis, TTP
C5a	ANCA-associated vasculitis
C1q/C1qR	C1q nephropathy
Properdin	TI injury due to massive proteinuria
C5	ANCA-associated vasculitis
Factor B	ANCA-associated vasculitis
CRaR	TI inflammation, IRI
C5aR	IRI
Factor H	IRI
C5b-9	IRI
CD59	IRI

DDD: Dense deposit disease; aHUS: Atypical hemolytic uremic syndrome; C3GN: C3 glomerulonephritis; MCP: Membrane co-factor protein; CFHR5: Complement factor H-related protein; ANCA: Anti neutrophil cytoplasmic antibody; C3Nef: C3 nephritic factor; TTP: Thrombotic thrombocytopenic purpura; TI: Tubulo-interstitial; IRI: Ischemia-reperfusion-injury.

Citation: Salvadori M, Rosso G, Bertoni E. Complement involvement in kidney diseases: From physiopathology to therapeutical targeting. World J Nephrol 2015; 4(2): 169-184
URL: https://www.wjgnet.com/2220-6124/full/v4/i2/169.htm
DOI: https://dx.doi.org/10.5527/wjn.v4.i2.169