Are phosphodiesterase type 5 inhibitors effective for the management of lower urinary symptoms suggestive of benign prostatic hyperplasia?

Table 1 Characteristics and qualities of the studies included in the analysis of tadalafil, sildenafil and vardenafil

Ref.	Sample	Drug (mg)		Duration	Run-in	Inclusion criteria	Publications
	size	Trial	Control	(wk)	period (wk)
Tadalafil
Brock et al[39]	1089	5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	BJU Int
Dmochowski et al[13]	200	20	Placebo	12	4	Mean age ≥ 40, LUTS/BPH ≥ 6 mo, IPSS ≥ 13	J Urol
Donatucci et al[14]	427	2.5, 5, 10, 20	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13	BJU Int
Egerdie et al[15]	606	2.5, 5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	J Sex Med
Kim et al[16]	102	5	Placebo	12	6	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	LUTS
McVary et al[18]	281	5 + 20	Placebo	6 + 6	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	J Urol
Oelke et al[19]	343	5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	Eur Urol
Porst et al[21]	581	2.5, 5, 10, 20	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	Eur Urol
Porst et al[36]	325	5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	Eur Urol
Porst et al[20]	1500	5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	Urology
Roehrborn et al[22]	1058	2.5, 5, 10, 20	Placebo	12	4	Mean age ≥ 45-60, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s, PVR 150-550 mL	J Urol
Roehrborn et al[12]	1500	5	Placebo	12	4	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s	J Urol
Takeda et al[24]	610	5	Placebo	12	4	Mean age ≥ 40, LUTS/BPH ≥ 6 mo, IPSS ≥ 13	J Urol
Yokoyama et al[25]	460	2.5, 5	Placebo	12	2	Mean age ≥ 45, LUTS/BPH ≥ 6 mo, IPSS ≥ 13 Qmax 4-15 mL/s, prostate volume ≥ 20 mL	Int J Urol
Sildenafil
McVary et al[10]	369	50, 100	Placebo	12	4	Mean age ≥ 45, IIEF ≤ 25, IPSS ≥ 12	J Urol
Vardenafil
Stief et al[40]	222	10	Placebo	8	4	Mean age ≥ 45-64, LUTS/BPH ≥ 6 mo, IPSS ≥ 12	Eur Urol

IIEF: International index of erectile function; IPSS: International prostate symptom; LUTS/BPH: Lower urinary tract symptoms/benign prostatic hyperplasia; Qmax: Maximum urinary flow rate; PVR: Post-void residual volume.